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Antimalarial Activity of C-10 Substituted Triazolyl Artemisinin

We synthesized C-10 substituted triazolyl artemisinins by the Huisgen cycloaddition reaction between dihydroartemisinins (2) and variously substituted 1, 2, 3-triazoles (8a-8h). The antimalarial activities of 32 novel artemisinin derivatives were screened against a chloroquine-resistant parasite. Am...

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Detalles Bibliográficos
Autores principales: Park, Gab-Man, Park, Hyun, Oh, Sangtae, Lee, Seokjoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Parasitology and Tropical Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776900/
https://www.ncbi.nlm.nih.gov/pubmed/29320822
http://dx.doi.org/10.3347/kjp.2017.55.6.661