Cargando…

Cytotoxic effect of Efavirenz in BxPC-3 pancreatic cancer cells is based on oxidative stress and is synergistic with ionizing radiation

The non-nucleoside reverse transcriptase inhibitor (NNRTI) Efavirenz is frequently used in human immunodeficiency virus treatment, but also efficient against cancer in mouse models. Its radiosensitizing effect makes it a promising drug for combination with radiotherapy. The efficacy of Efavirenz com...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hecht, Markus, Harrer, Thomas, Körber, Verena, Sarpong, Eric O., Moser, Fabian, Fiebig, Nora, Schwegler, Manuela, Stürzl, Michael, Fietkau, Rainer, Distel, Luitpold V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776903/ https://www.ncbi.nlm.nih.gov/pubmed/29434868 http://dx.doi.org/10.3892/ol.2017.7523

Ejemplares similares

Efavirenz Has the Highest Anti-Proliferative Effect of Non-Nucleoside Reverse Transcriptase Inhibitors against Pancreatic Cancer Cells
por: Hecht, Markus, et al.
Publicado: (2015)

Antiproliferative effect of alpinetin in BxPC-3 pancreatic cancer cells
por: DU, JIAN, et al.
Publicado: (2012)

Antiproliferative effect of alpinetin in BxPC-3 pancreatic cancer cells
por: Du, Jian, et al.
Publicado: (2023)

Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells
por: Hannon, Gary, et al.
Publicado: (2020)

Intracellular Distributing and Interferon-γ Secretion of Human Interleukin-18 in BxPC-3 Cells
por: Yang, Jin, et al.
Publicado: (2014)

Implications of Targeted Genomic Disruption of β-Catenin in BxPC-3 Pancreatic Adenocarcinoma Cells
por: Olsen, Petter Angell, et al.
Publicado: (2014)

Oridonin alters the expression profiles of MicroRNAs in BxPC-3 human pancreatic cancer cells
por: Gui, Zhifang, et al.
Publicado: (2015)

Proton Therapy, Magnetic Nanoparticles and Hyperthermia as Combined Treatment for Pancreatic BxPC3 Tumor Cells
por: Brero, Francesca, et al.
Publicado: (2023)

Effects of Metallic and Carbon-Based Nanomaterials on Human Pancreatic Cancer Cell Lines AsPC-1 and BxPC-3
por: Wójcik, Barbara, et al.
Publicado: (2021)

Enhanced tumor targeting of cRGD peptide-conjugated albumin nanoparticles in the BxPC-3 cell line
por: Yu, Xinzhe, et al.
Publicado: (2016)

Expression profiling of wild type and β-catenin gene disrupted human BxPC-3 pancreatic adenocarcinoma cells
por: Olsen, Petter Angell, et al.
Publicado: (2015)

Comparative analysis of Notch1 and Notch2 binding sites in the genome of BxPC3 pancreatic cancer cells
por: Liu, Hao, et al.
Publicado: (2017)

Silencing NEDD9 by lentivirus-delivered shRNA inhibits the growth of BxPC-3 cells in vitro and in vivo
por: Wu, Tielong, et al.
Publicado: (2019)

Phenolic alkaloids from Menispermum dauricum inhibits BxPC-3 pancreatic cancer cells by blocking of Hedgehog signaling pathway
por: Zhou, Zhong-guang, et al.
Publicado: (2015)

Inhibitory Effect of the HASPIN Inhibitor CHR-6494 on BxPC-3-Luc, A Luciferase-Expressing Pancreatic Cancer Cell Line
por: Tanaka, Hiromitsu, et al.
Publicado: (2022)

PARP inhibitors combined with ionizing radiation induce different effects in melanoma cells and healthy fibroblasts
por: Weigert, Verena, et al.
Publicado: (2020)

Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells
por: Dobler, Clara, et al.
Publicado: (2020)

MS-5, a Naphthalene Derivative, Induces Apoptosis in Human Pancreatic Cancer BxPC-3 Cells by Modulating Reactive Oxygen Species
por: Giri, Suman, et al.
Publicado: (2023)

BxPC3 pancreatic cancer cells express a truncated Smad4 protein upon PI3K and mTOR inhibition
por: LEGENDRE, ONICA, et al.
Publicado: (2014)

BxPC-3-Derived Small Extracellular Vesicles Induce FOXP3+ Treg through ATM-AMPK-Sirtuins-Mediated FOXOs Nuclear Translocations
por: Shen, Tao, et al.
Publicado: (2020)

Salidroside ameliorated hypoxia‐induced tumorigenesis of BxPC‐3 cells via downregulating hypoxia‐inducible factor (HIF)‐1α and LOXL2
por: Chen, Xiaoping, et al.
Publicado: (2019)

The natural sulfoglycolipid derivative SQAP improves the therapeutic efficacy of tissue factor-targeted radioimmunotherapy in the stroma-rich pancreatic cancer model BxPC-3
por: Takakusagi, Yoichi, et al.
Publicado: (2021)

Dickkopf-related protein 3 alters aerobic glycolysis in pancreatic cancer BxPC-3 cells, promoting CD4(+) T-cell activation and function
por: Guo, Qingqu, et al.
Publicado: (2021)

PARP Inhibitors Talazoparib and Niraparib Sensitize Melanoma Cells to Ionizing Radiation
por: Jonuscheit, Stephanie, et al.
Publicado: (2021)

Expression of Selected miRNAs in Normal and Cancer-Associated Fibroblasts and in BxPc3 and MIA PaCa-2 Cell Lines of Pancreatic Ductal Adenocarcinoma
por: Mandys, Václav, et al.
Publicado: (2023)

Influence of alectinib and crizotinib on ionizing radiation - in vitro analysis of ALK/ROS1-wildtype lung tissue cells
por: Jost, Tina, et al.
Publicado: (2022)

Dihomo-γ-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA
por: Yang, Xiaoyu, et al.
Publicado: (2018)

Response gene to complement-32 enhances metastatic phenotype by mediating transforming growth factor beta-induced epithelial-mesenchymal transition in human pancreatic cancer cell line BxPC-3
por: Zhu, Liang, et al.
Publicado: (2012)

ASF-4-1 fibroblast-rich culture increases chemoresistance and mTOR expression of pancreatic cancer BxPC-3 cells at the invasive front in vitro, and promotes tumor growth and invasion in vivo
por: FUJIWARA, MASAYA, et al.
Publicado: (2016)

Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells
por: Faulhaber, Eva-Maria, et al.
Publicado: (2021)

The Effect of Xevinapant Combined with Ionizing Radiation on HNSCC and Normal Tissue Cells and the Impact of Xevinapant on Its Targeted Proteins cIAP1 and XIAP
por: Fleischmann, Julia, et al.
Publicado: (2023)

Role of tumor cell senescence in non-professional phagocytosis and cell-in-cell structure formation
por: Gottwald, Dorian, et al.
Publicado: (2020)

Deterioration of Health-Related Quality of Life Scores under Treatment Predicts Longer Survival
por: Jörling, Maike, et al.
Publicado: (2020)

Palbociclib Induces Senescence in Melanoma and Breast Cancer Cells and Leads to Additive Growth Arrest in Combination With Irradiation
por: Jost, Tina, et al.
Publicado: (2021)

Differences in and Prognostic Value of Quality of Life Data in Rectal Cancer Patients with and without Distant Metastases
por: Frank, Fabian, et al.
Publicado: (2020)

Dual mTOR/DNA-PK Inhibitor CC-115 Induces Cell Death in Melanoma Cells and Has Radiosensitizing Potential
por: Bürkel, Felix, et al.
Publicado: (2020)

Efficacy Evaluation of Combination Treatment Using Gemcitabine and Radioimmunotherapy with (90)Y-Labeled Fully Human Anti-CD147 Monoclonal Antibody 059-053 in a BxPC-3 Xenograft Mouse Model of Refractory Pancreatic Cancer
por: Sugyo, Aya, et al.
Publicado: (2018)

Ex Vivo Apoptosis in CD8+ Lymphocytes Predicts Rectal Cancer Patient Outcome
por: Winkler, Sebastian, et al.
Publicado: (2016)

Baseline Quality of Life of Physical Function Is Highly Relevant for Overall Survival in Advanced Rectal Cancer
por: Fitz, Tim, et al.
Publicado: (2022)

PML-nuclear bodies decrease with age and their stress response is impaired in aged individuals
por: Wenger, Barbara, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_nni91u7e2sag3v2imjrrg49la8