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RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases

Directed migration is essential for cell motility in many processes, including development and cancer cell invasion. RSKs (p90 ribosomal S6 kinases) have emerged as central regulators of cell migration; however, the mechanisms mediating RSK-dependent motility remain incompletely understood. We have...

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Detalles Bibliográficos
Autores principales: Shi, Geng-Xian, Yang, Won Seok, Jin, Ling, Matter, Michelle L., Ramos, Joe W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777029/
https://www.ncbi.nlm.nih.gov/pubmed/29279389
http://dx.doi.org/10.1073/pnas.1708584115