Upregulation of pyruvate kinase M2 expression by fatty acid synthase contributes to gemcitabine resistance in pancreatic cancer

Pancreatic cancer has one of the highest mortality rates of all cancer types. Fatty acid synthase (FASN) is a multifunctional protein homodimer that can convert acetyl coenzyme A (CoA) and malonyl-CoA into palmitate, thus regulating lipogenesis. FASN overexpression has also been shown to cause resis...

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Detalles Bibliográficos
Autores principales: Tian, Shenghua, Li, Pingping, Sheng, Shi, Jin, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777098/
https://www.ncbi.nlm.nih.gov/pubmed/29434927
http://dx.doi.org/10.3892/ol.2017.7598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777098/
https://www.ncbi.nlm.nih.gov/pubmed/29434927
http://dx.doi.org/10.3892/ol.2017.7598

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