Predicting CYP3A‐mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure

AIMS: Inflammation and organ failure have been reported to have an impact on cytochrome P450 (CYP) 3A‐mediated clearance of midazolam in critically ill children. Our aim was to evaluate a previously developed population pharmacokinetic model both in critically ill children and other populations, in...

Descripción completa

Detalles Bibliográficos
Autores principales: Brussee, Janneke M., Vet, Nienke J., Krekels, Elke H. J., Valkenburg, Abraham J., Jacqz‐Aigrain, Evelyne, van Gerven, Joop M. A., Swart, Eleonora L., van den Anker, Johannes N., Tibboel, Dick, de Hoog, Matthijs, de Wildt, Saskia N., Knibbe, Catherijne A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Paediatric Clinical Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777436/
https://www.ncbi.nlm.nih.gov/pubmed/29072785
http://dx.doi.org/10.1111/bcp.13459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777436/
https://www.ncbi.nlm.nih.gov/pubmed/29072785
http://dx.doi.org/10.1111/bcp.13459

Ejemplares similares