Efficacy of decitabine-loaded gelatinases-stimuli nanoparticles in overcoming cancer drug resistance is mediated via its enhanced demethylating activity to transcription factor AP-2 epsilon

Hypermethylation of the transcription factor AP-2 epsilon (TFAP2E) gene affects 5-fluorouridine (5-FU) resistance in gastric cancer (GC) patients. The epigenetic inhibitor 5-Aza-2′-deoxycytidine (DAC), which reverses DNA methylation by targeting DNA methyltransferases (DNMTs), has potential to sensi...

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Detalles Bibliográficos
Autores principales: Hong, Yi-Dong, Zhang, Jian, Zhuang, Ming, Li, Wei, Wu, Puy-Uan, Li, Ru-Tian, Hu, Nan, Bian, Bao-Xiang, Song, Zi-Yan, Wu, Feng-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777709/
https://www.ncbi.nlm.nih.gov/pubmed/29383097
http://dx.doi.org/10.18632/oncotarget.21274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777709/
https://www.ncbi.nlm.nih.gov/pubmed/29383097
http://dx.doi.org/10.18632/oncotarget.21274

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