CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway

Cancer cells exhibit an abnormal amino acid metabolism and a dependence on specific amino acids, which might provide potential targets for treating cancer patients. In this study, we demonstrated that human triple negative breast cancer (TNBC) cells were highly susceptible to cystine starvation. We...

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Detalles Bibliográficos
Autores principales: Chen, Meng-Shian, Wang, Sheng-Fan, Hsu, Chih-Yi, Yin, Pen-Hui, Yeh, Tien-Shun, Lee, Hsin-Chen, Tseng, Ling-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777716/
https://www.ncbi.nlm.nih.gov/pubmed/29383104
http://dx.doi.org/10.18632/oncotarget.23055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777716/
https://www.ncbi.nlm.nih.gov/pubmed/29383104
http://dx.doi.org/10.18632/oncotarget.23055

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