Apancreatic pigs cloned using Pdx1-disrupted fibroblasts created via TALEN-mediated mutagenesis

Pancreatic and duodenal homeobox 1 (PDX1) plays a crucial role in pancreas development, β-cell differentiation, and maintenance of mature β-cell function. In this study, we designed a strategy to produce PDX1-knockout (KO) pigs. A transcription activator-like effector nuclease (TALEN) pair targeting...

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Detalles Bibliográficos
Autores principales: Kang, Jin-Dan, Kim, Hyojin, Jin, Long, Guo, Qing, Cui, Cheng-Du, Li, Wen-Xue, Kim, Seokjoong, Kim, Jin-Soo, Yin, Xi-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777787/
https://www.ncbi.nlm.nih.gov/pubmed/29383175
http://dx.doi.org/10.18632/oncotarget.23301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777787/
https://www.ncbi.nlm.nih.gov/pubmed/29383175
http://dx.doi.org/10.18632/oncotarget.23301

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