Structural basis of thalidomide enantiomer binding to cereblon

Thalidomide possesses two optical isomers which have been reported to exhibit different pharmacological and toxicological activities. However, the precise mechanism by which the two isomers exert their different activities remains poorly understood. Here, we present structural and biochemical studie...

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Detalles Bibliográficos
Autores principales: Mori, Tomoyuki, Ito, Takumi, Liu, Shujie, Ando, Hideki, Sakamoto, Satoshi, Yamaguchi, Yuki, Tokunaga, Etsuko, Shibata, Norio, Handa, Hiroshi, Hakoshima, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778007/
https://www.ncbi.nlm.nih.gov/pubmed/29358579
http://dx.doi.org/10.1038/s41598-018-19202-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778007/
https://www.ncbi.nlm.nih.gov/pubmed/29358579
http://dx.doi.org/10.1038/s41598-018-19202-7

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