Cargando…

GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth

Epidermal growth factor receptor (EGFR) signaling and its downregulation upon ligand binding have been extensively documented. However, the mechanisms by which cells maintain steady-state EGFR expression remain poorly understood. Here, we report a novel role of Golgi-localized, γ-adaptin ear-contain...

Descripción completa

Detalles Bibliográficos
Autores principales: Uemura, Takefumi, Kametaka, Satoshi, Waguri, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778047/
https://www.ncbi.nlm.nih.gov/pubmed/29358589
http://dx.doi.org/10.1038/s41598-018-19542-4