Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice

Sperm entry in mammalian oocytes triggers intracellular Ca(2+) oscillations that initiate resumption of the meiotic cell cycle and subsequent activations. Here, we show that phospholipase C zeta 1 (PLCζ1) is the long-sought sperm-borne oocyte activation factor (SOAF). Plcz1 gene knockout (KO) mouse...

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Detalles Bibliográficos
Autores principales: Nozawa, Kaori, Satouh, Yuhkoh, Fujimoto, Takao, Oji, Asami, Ikawa, Masahito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778054/
https://www.ncbi.nlm.nih.gov/pubmed/29358633
http://dx.doi.org/10.1038/s41598-018-19497-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778054/
https://www.ncbi.nlm.nih.gov/pubmed/29358633
http://dx.doi.org/10.1038/s41598-018-19497-6

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