Perspective on Protein Arginine Deiminase Activity—Bicarbonate Is a pH-Independent Regulator of Citrullination

Protein citrullination catalyzed by peptidyl arginine deiminase (PADs) is involved in autoimmune disease pathogenesis, especially in rheumatoid arthritis. Calcium is a key regulator of PAD activity, but under normal physiological conditions it remains uncertain how intracellular calcium levels can b...

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Detalles Bibliográficos
Autores principales: Zhou, Yebin, Mittereder, Nanette, Sims, Gary P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778117/
https://www.ncbi.nlm.nih.gov/pubmed/29403504
http://dx.doi.org/10.3389/fimmu.2018.00034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778117/
https://www.ncbi.nlm.nih.gov/pubmed/29403504
http://dx.doi.org/10.3389/fimmu.2018.00034

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