Efficient RNA pseudouridylation by eukaryotic H/ACA ribonucleoproteins requires high affinity binding and correct positioning of guide RNA

H/ACA ribonucleoproteins (H/ACA RNPs) are responsible for introducing many pseudouridines into RNAs, but are also involved in other cellular functions. Utilizing a purified and reconstituted yeast H/ACA RNP system that is active in pseudouridine formation under physiological conditions, we describe...

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Detalles Bibliográficos
Autores principales: Caton, Evan A, Kelly, Erin K, Kamalampeta, Rajashekhar, Kothe, Ute
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778458/
https://www.ncbi.nlm.nih.gov/pubmed/29177505
http://dx.doi.org/10.1093/nar/gkx1167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778458/
https://www.ncbi.nlm.nih.gov/pubmed/29177505
http://dx.doi.org/10.1093/nar/gkx1167

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