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AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression
BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) mutations represent the most common genetic cause of sporadic and familial Parkinson’s disease (PD). Especially, LRRK2 G2019S missense mutation has been identified as the most prevalent genetic cause in the late-onset PD. Advanced glycation end produc...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778750/ https://www.ncbi.nlm.nih.gov/pubmed/29387348 http://dx.doi.org/10.1186/s40035-018-0106-z |