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Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A

Impairment of neurogenesis in the hippocampus following whole-brain irradiation is the most important mechanism of radiation-induced cognitive dysfunction. However, the underlying mechanism remains obscure, meaning an ideal therapeutic target has not been identified. Evidence indicates that DNA meth...

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Detalles Bibliográficos
Autores principales: Ji, Shengjun, Ding, Xin, Ji, Jiang, Wu, Haohao, Sun, Rui, Li, Xiaoyang, Zhang, Liyuan, Tian, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778827/
https://www.ncbi.nlm.nih.gov/pubmed/29435016
http://dx.doi.org/10.3892/ol.2017.7643