Matrine‐Type Alkaloids Inhibit Advanced Glycation End Products Induced Reactive Oxygen Species‐Mediated Apoptosis of Aortic Endothelial Cells In Vivo and In Vitro by Targeting MKK3 and p38MAPK Signaling

BACKGROUND: The matrine‐type alkaloids are bioactive components extracted from Sophora flavescens, which is used in treatment of diabetes mellitus in traditional Chinese medicine. Advanced glycation end products mediate diabetic vascular complications. This study was aimed to investigate the protect...

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Detalles Bibliográficos
Autores principales: Liu, Zhongwei, Lv, Ying, Zhang, Yong, Liu, Fuqiang, Zhu, Ling, Pan, Shuo, Qiu, Chuan, Guo, Yan, Yang, Tielin, Wang, Junkui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779049/
https://www.ncbi.nlm.nih.gov/pubmed/29197828
http://dx.doi.org/10.1161/JAHA.117.007441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779049/
https://www.ncbi.nlm.nih.gov/pubmed/29197828
http://dx.doi.org/10.1161/JAHA.117.007441

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