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Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes

BACKGROUND: Cardiac sodium channel (NaV1.5) dysfunction contributes to arrhythmogenesis during pathophysiological conditions. Nav1.5 localizes to distinct subcellular microdomains within the cardiomyocyte, where it associates with region‐specific proteins, yielding complexes whose function is locati...

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Detalles Bibliográficos
Autores principales: Rivaud, Mathilde R., Agullo‐Pascual, Esperanza, Lin, Xianming, Leo‐Macias, Alejandra, Zhang, Mingliang, Rothenberg, Eli, Bezzina, Connie R., Delmar, Mario, Remme, Carol Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779058/
https://www.ncbi.nlm.nih.gov/pubmed/29222390
http://dx.doi.org/10.1161/JAHA.117.007622