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DNA Methyltransferase 1–Dependent DNA Hypermethylation Constrains Arteriogenesis by Augmenting Shear Stress Set Point

BACKGROUND: Arteriogenesis is initiated by increased shear stress and is thought to continue until shear stress is returned to its original “set point.” However, the molecular mechanism(s) through which shear stress set point is established by endothelial cells (ECs) are largely unstudied. Here, we...

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Detalles Bibliográficos
Autores principales: Heuslein, Joshua L., Gorick, Catherine M., Song, Ji, Price, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779061/
https://www.ncbi.nlm.nih.gov/pubmed/29191807
http://dx.doi.org/10.1161/JAHA.117.007673