Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast

Aneuploidy and epigenetic alterations have long been associated with carcinogenesis, but it was unknown whether aneuploidy could disrupt the epigenetic states required for cellular differentiation. In this study, we found that ~3% of random aneuploid karyotypes in yeast disrupt the stable inheritanc...

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Detalles Bibliográficos
Autores principales: Mulla, Wahid A, Seidel, Chris W, Zhu, Jin, Tsai, Hung-Ji, Smith, Sarah E, Singh, Pushpendra, Bradford, William D, McCroskey, Scott, Nelliat, Anjali R, Conkright, Juliana, Peak, Allison, Malanowski, Kathryn E, Perera, Anoja G, Li, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779231/
https://www.ncbi.nlm.nih.gov/pubmed/28841138
http://dx.doi.org/10.7554/eLife.27991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779231/
https://www.ncbi.nlm.nih.gov/pubmed/28841138
http://dx.doi.org/10.7554/eLife.27991

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