Cdc73 suppresses genome instability by mediating telomere homeostasis

Defects in the genes encoding the Paf1 complex can cause increased genome instability. Loss of Paf1, Cdc73, and Ctr9, but not Rtf1 or Leo1, caused increased accumulation of gross chromosomal rearrangements (GCRs). Combining the cdc73Δ mutation with individual deletions of 43 other genes, including T...

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Detalles Bibliográficos
Autores principales: Nene, Rahul V., Putnam, Christopher D., Li, Bin-Zhong, Nguyen, Katarina G., Srivatsan, Anjana, Campbell, Christopher S., Desai, Arshad, Kolodner, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779705/
https://www.ncbi.nlm.nih.gov/pubmed/29320491
http://dx.doi.org/10.1371/journal.pgen.1007170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779705/
https://www.ncbi.nlm.nih.gov/pubmed/29320491
http://dx.doi.org/10.1371/journal.pgen.1007170

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