Simvastatin attenuated rat thoracic aorta remodeling by decreasing ROCK2-mediated CyPA secretion and CD147-ERK1/2-cyclin pathway

Reactive oxygen species-induced cyclophilin A (CyPA) release from vascular smooth muscle cells (VSMCs) may be inhibited by simvastatin in vitro. The present study aimed to further examine the effect of simvastatin on serum CyPA levels and the basigin (CD147)-extracellular signal-regulated kinase (ER...

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Detalles Bibliográficos
Autores principales: Tang, Fu-Cai, Wang, Hong-Yan, Ma, Ming-Ming, Guan, Tian-Wang, Pan, Long, Yao, Dun-Chen, Chen, Ya-Lan, Li, Sheng-Jie, Yang, Hang, Zhu, Xiao-Qin, Tu, Yong-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779895/
https://www.ncbi.nlm.nih.gov/pubmed/28983618
http://dx.doi.org/10.3892/mmr.2017.7640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779895/
https://www.ncbi.nlm.nih.gov/pubmed/28983618
http://dx.doi.org/10.3892/mmr.2017.7640

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