Ultrasound-targeted microbubbles combined with a peptide nucleic acid binding nuclear localization signal mediate transfection of exogenous genes by improving cytoplasmic and nuclear import

The development of an efficient delivery system is critical for the successful treatment of cardiovascular diseases using non-viral gene therapies. Cytoplasmic and nuclear membrane barriers reduce delivery efficiency by impeding the transfection of foreign genes. Thus, a gene delivery system capable...

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Detalles Bibliográficos
Autores principales: Jiang, Nan, Chen, Qian, Cao, Sheng, Hu, Bo, Wang, Yi-Jia, Zhou, Qing, Guo, Rui-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779960/
https://www.ncbi.nlm.nih.gov/pubmed/28990051
http://dx.doi.org/10.3892/mmr.2017.7681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779960/
https://www.ncbi.nlm.nih.gov/pubmed/28990051
http://dx.doi.org/10.3892/mmr.2017.7681

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