Cargando…

Silencing of histone methyltransferase NSD3 reduces cell viability in osteosarcoma with induction of apoptosis

NSD3 is a histone lysine methyltransferase that methylates histone H3 at lysine 36. NSD3 is located at chromosome 8p11.23, the locus that exhibits strong cancer relevance. Thus, NSD3 is likely involved in multiple human cancers. Nevertheless, its roles in human carcinogenesis remain unknown. In the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Zhiwei, Piao, Lianhua, Zhuang, Ming, Qiu, Xubin, Xu, Xiaoshuang, Zhang, Dawei, Liu, Mengmeng, Ren, Ding
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780032/ https://www.ncbi.nlm.nih.gov/pubmed/28901481 http://dx.doi.org/10.3892/or.2017.5936

Ejemplares similares

The role of histone lysine methyltransferase NSD3 in cancer
por: Han, Xu, et al.
Publicado: (2018)

Histone methyltransferase NSD2 regulates apoptosis and chemosensitivity in osteosarcoma
por: He, Chao, et al.
Publicado: (2019)

Loss of histone H4 lysine 20 trimethylation in osteosarcoma is associated with aberrant expression ofhistone methyltransferase SUV420H2
por: Piao, Lianhua, et al.
Publicado: (2020)

NSD2 Promotes Renal Cancer Progression Through Stimulating Akt/Erk Signaling
por: Han, Xu, et al.
Publicado: (2020)

Covalent inhibition of NSD1 histone methyltransferase
por: Huang, Huang, et al.
Publicado: (2020)

Histone methyltransferase Nsd2 is required for follicular helper T cell differentiation
por: Long, Xuehui, et al.
Publicado: (2019)

The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate
por: Li, Yan, et al.
Publicado: (2009)

Identification of histone methyltransferase NSD2 as an important oncogenic gene in colorectal cancer
por: Zhao, Li-hao, et al.
Publicado: (2021)

Knockdown of NSD2 Suppresses Renal Cell Carcinoma Metastasis by Inhibiting Epithelial-Mesenchymal Transition
por: Han, Xu, et al.
Publicado: (2019)

An Activating Mutation of the NSD2 Histone Methyltransferase Drives Oncogenic Reprogramming in Acute Lymphocytic Leukemia
por: Swaroop, Alok, et al.
Publicado: (2018)

In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L
por: Morishita, Masayo, et al.
Publicado: (2014)

Structure, Activity and Function of the NSD3 Protein Lysine Methyltransferase
por: Rathert, Philipp
Publicado: (2021)

Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma?
por: Krossa, Imène, et al.
Publicado: (2022)

Erythrocyte membrane protein band 4.1-like 3 inhibits osteosarcoma cell invasion through regulation of Snai1-induced epithelial-to-mesenchymal transition
por: Yuan, Xiaofeng, et al.
Publicado: (2020)

NSD1: A Lysine Methyltransferase between Developmental Disorders and Cancer
por: Tauchmann, Samantha, et al.
Publicado: (2021)

Cellular functions and molecular mechanisms of ubiquitination in osteosarcoma
por: Song, Jiaxun, et al.
Publicado: (2022)

P1347: H3K36 HISTONE METHYLTRANSFERASE NSD3 FUNCTIONS AS A CRUCIAL EPIGENETIC REGULATOR OF ERYTHROPOIESIS
por: Shah, Arunim, et al.
Publicado: (2023)

Overexpression of EZH2/NSD2 Histone Methyltransferase Axis Predicts Poor Prognosis and Accelerates Tumor Progression in Triple-Negative Breast Cancer
por: Gao, Bo, et al.
Publicado: (2021)

In silico derived small molecules targeting the finger-finger interaction between the histone lysine methyltransferase NSD1 and Nizp1 repressor
por: Berardi, Andrea, et al.
Publicado: (2020)

The Role of Methyltransferase NSD2 as a Potential Oncogene in Human Solid Tumors
por: Chen, Rui, et al.
Publicado: (2020)

Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases
por: Li, Wanqiu, et al.
Publicado: (2020)

Understanding the Roles of the NSD Protein Methyltransferases in Head and Neck Squamous Cell Carcinoma
por: Murali, Madhavi, et al.
Publicado: (2022)

Epigenetic Silencing of CHOP Expression by the Histone Methyltransferase EHMT1 Regulates Apoptosis in Colorectal Cancer Cells
por: Kim, Kwangho, et al.
Publicado: (2022)

Steric Clash in the SET Domain of Histone Methyltransferase NSD1 as a Cause of Sotos Syndrome and Its Genetic Heterogeneity in a Brazilian Cohort
por: Ha, Kyungsoo, et al.
Publicado: (2016)

Automethylation of SUV39H2, an oncogenic histone lysine methyltransferase, regulates its binding affinity to substrate proteins
por: Piao, Lianhua, et al.
Publicado: (2016)

Attenuation of Histone Methyltransferase KRYPTONITE-mediated transcriptional gene silencing by Geminivirus
por: Sun, Yan-Wei, et al.
Publicado: (2015)

Neural crest specification and migration independently require NSD3-related lysine methyltransferase activity
por: Jacques-Fricke, Bridget T., et al.
Publicado: (2014)

The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence‐associated epigenomic remodeling
por: Tanaka, Hiroshi, et al.
Publicado: (2020)

H3K36me2 methyltransferase NSD2 orchestrates epigenetic reprogramming during spermatogenesis
por: Li, Zhiming, et al.
Publicado: (2022)

Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
por: Zhuang, Lenan, et al.
Publicado: (2018)

A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing
por: Kato, Masaki, et al.
Publicado: (2018)

The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3
por: Wang, Chunmei, et al.
Publicado: (2017)

Elevated NSD3 Histone Methylation Activity Drives Squamous Cell Lung Cancer
por: Yuan, Gang, et al.
Publicado: (2021)

MicroRNAs with prognostic significance in osteosarcoma: a systemic review and meta-analysis
por: Cheng, Dong, et al.
Publicado: (2017)

New Small Molecules Targeting Apoptosis and Cell Viability in Osteosarcoma
por: Maugg, Doris, et al.
Publicado: (2015)

H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair
por: Shao, Rui, et al.
Publicado: (2021)

Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer
por: Taniguchi, H, et al.
Publicado: (2012)

Low expression of NSD1, NSD2, and NSD3 define a subset of human papillomavirus-positive oral squamous carcinomas with unfavorable prognosis
por: Gameiro, Steven F., et al.
Publicado: (2021)

Histone Methyltransferases as Therapeutic Targets for Kidney Diseases
por: Yu, Chao, et al.
Publicado: (2019)

The histone methyltransferase SMYD2 is a novel therapeutic target for the induction of apoptosis in ovarian clear cell carcinoma cells
por: Kojima, Machiko, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_muck2r638o19l39enuiavvfdjv