A hypoxia- and telomerase-responsive oncolytic adenovirus expressing secretable trimeric TRAIL triggers tumour-specific apoptosis and promotes viral dispersion in TRAIL-resistant glioblastoma

Glioblastoma is a highly aggressive and malignant type of cancer that is apoptosis resistant and difficult to cure by conventional cancer therapies. In this regard, an oncolytic adenovirus that selectively targets the tumour tissue and induces tumour cell lysis is a promising treatment option. We de...

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Detalles Bibliográficos
Autores principales: Oh, Eonju, Hong, JinWoo, Kwon, Oh-Joon, Yun, Chae-Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780382/
https://www.ncbi.nlm.nih.gov/pubmed/29362367
http://dx.doi.org/10.1038/s41598-018-19300-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780382/
https://www.ncbi.nlm.nih.gov/pubmed/29362367
http://dx.doi.org/10.1038/s41598-018-19300-6

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