Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation

Heavy menstrual bleeding (HMB) is common and debilitating, and often requires surgery due to hormonal side effects from medical therapies. Here we show that transient, physiological hypoxia occurs in the menstrual endometrium to stabilise hypoxia inducible factor 1 (HIF-1) and drive repair of the de...

Descripción completa

Detalles Bibliográficos
Autores principales: Maybin, Jacqueline A., Murray, Alison A., Saunders, Philippa T. K., Hirani, Nikhil, Carmeliet, Peter, Critchley, Hilary O. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780386/
https://www.ncbi.nlm.nih.gov/pubmed/29362355
http://dx.doi.org/10.1038/s41467-017-02375-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780386/
https://www.ncbi.nlm.nih.gov/pubmed/29362355
http://dx.doi.org/10.1038/s41467-017-02375-6

Ejemplares similares