Copper(I)-binding properties of de-coppering drugs for the treatment of Wilson disease. α-Lipoic acid as a potential anti-copper agent

Wilson disease is an autosomal recessive genetic disorder caused by loss-of-function mutations in the P-type copper ATPase, ATP7B, which leads to toxic accumulation of copper mainly in the liver and brain. Wilson disease is treatable, primarily by copper-chelation therapy, which promotes copper excr...

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Detalles Bibliográficos
Autores principales: Smirnova, Julia, Kabin, Ekaterina, Järving, Ivar, Bragina, Olga, Tõugu, Vello, Plitz, Thomas, Palumaa, Peep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780470/
https://www.ncbi.nlm.nih.gov/pubmed/29362485
http://dx.doi.org/10.1038/s41598-018-19873-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780470/
https://www.ncbi.nlm.nih.gov/pubmed/29362485
http://dx.doi.org/10.1038/s41598-018-19873-2

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