Effects of ambroxol on the autophagy-lysosome pathway and mitochondria in primary cortical neurons

Glucocerebrosidase (GBA1) mutations are the major genetic risk factor for Parkinson’s Disease (PD). The pathogenic mechanism is still unclear, but alterations in lysosomal-autophagy processes are implicated due to reduction of mutated glucocerebrosidase (GCase) in lysosomes. Wild-type GCase activity...

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Detalles Bibliográficos
Autores principales: Magalhaes, J., Gegg, M. E., Migdalska-Richards, A., Schapira, A. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780491/
https://www.ncbi.nlm.nih.gov/pubmed/29362387
http://dx.doi.org/10.1038/s41598-018-19479-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780491/
https://www.ncbi.nlm.nih.gov/pubmed/29362387
http://dx.doi.org/10.1038/s41598-018-19479-8

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