Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination

The regulation of Rac1 by HACE1-mediated ubiquitination and proteasomal degradation is emerging as an essential element in the maintenance of cell homeostasis. However, how the E3 ubiquitin ligase activity of HACE1 is regulated remains undetermined. Using a proteomic approach, we identified serine 3...

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Detalles Bibliográficos
Autores principales: Acosta, Maria I., Urbach, Serge, Doye, Anne, Ng, Yuen-Wai, Boudeau, Jérôme, Mettouchi, Amel, Debant, Anne, Manser, Edward, Visvikis, Orane, Lemichez, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780496/
https://www.ncbi.nlm.nih.gov/pubmed/29362425
http://dx.doi.org/10.1038/s41598-018-19471-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780496/
https://www.ncbi.nlm.nih.gov/pubmed/29362425
http://dx.doi.org/10.1038/s41598-018-19471-2

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