Discovery of novel bacterial topoisomerase I inhibitors by use of in silico docking and in vitro assays

Topoisomerases are important targets for antibacterial and anticancer therapies. Bacterial topoisomerase I remains to be exploited for antibiotics that can be used in the clinic. Inhibitors of bacterial topoisomerase I may provide leads for novel antibacterial drugs against pathogens resistant to cu...

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Detalles Bibliográficos
Autores principales: Sandhaus, Shayna, Chapagain, Prem P., Tse-Dinh, Yuk-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780498/
https://www.ncbi.nlm.nih.gov/pubmed/29362471
http://dx.doi.org/10.1038/s41598-018-19944-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780498/
https://www.ncbi.nlm.nih.gov/pubmed/29362471
http://dx.doi.org/10.1038/s41598-018-19944-4

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