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Discovery of cell-type specific DNA motif grammar in cis-regulatory elements using random Forest

BACKGROUND: It has been observed that many transcription factors (TFs) can bind to different genomic loci depending on the cell type in which a TF is expressed in, even though the individual TF usually binds to the same core motif in different cell types. How a TF can bind to the genome in such a hi...

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Detalles Bibliográficos
Autores principales: Wang, Xin, Lin, Peijie, Ho, Joshua W. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780765/
https://www.ncbi.nlm.nih.gov/pubmed/29363433
http://dx.doi.org/10.1186/s12864-017-4340-z