Identification of danthron as an isoform-specific inhibitor of HEME OXYGENASE-1/cytochrome P450 reductase interaction with anti-tumor activity

BACKGROUND: Heme oxygenase (HO) catalyzes NADPH-dependent degradation of heme to liberate iron, carbon monoxide and biliverdin. The interaction between HO and cytochrome P450 reductase (CPR), an electron donor, is essential for HO activity. HO-1 is a stress-inducible isoform whereas HO-2 is constitu...

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Detalles Bibliográficos
Autores principales: Chou, Yi-Tai, Hsu, Fu-Fei, Hu, Dun-Yao, Chen, Ying-Chih, Hsu, Yuan-Hao, Hsu, John T.-A., Chau, Lee-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5781335/
https://www.ncbi.nlm.nih.gov/pubmed/29361943
http://dx.doi.org/10.1186/s12929-018-0411-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5781335/
https://www.ncbi.nlm.nih.gov/pubmed/29361943
http://dx.doi.org/10.1186/s12929-018-0411-y

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