A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of I(k1) Ion Channels in Real-Time

An important aspect of the Comprehensive In Vitro Proarrhythmia Assay (CiPA) proposal is the use of human stem cell-derived cardiomyocytes and the confirmation of their predictive power in drug safety assays. The benefits of this cell source are clear; drugs can be tested in vitro on human cardiomyo...

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Detalles Bibliográficos
Autores principales: Goversen, Birgit, Becker, Nadine, Stoelzle-Feix, Sonja, Obergrussberger, Alison, Vos, Marc A., van Veen, Toon A. B., Fertig, Niels, de Boer, Teun P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782795/
https://www.ncbi.nlm.nih.gov/pubmed/29403387
http://dx.doi.org/10.3389/fphys.2017.01094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782795/
https://www.ncbi.nlm.nih.gov/pubmed/29403387
http://dx.doi.org/10.3389/fphys.2017.01094

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