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Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout
To investigate the role of diacylglycerol kinase θ (DGKθ) in lipid metabolism and insulin resistance, the present study generated an in vitro hepatic steatosis cell model by knockout of the DGKθ gene in liver cancer cell line HepG2 using CRISPR/Cas9 technology. The cell line was characterized by Oil...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
D.A. Spandidos
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783457/ https://www.ncbi.nlm.nih.gov/pubmed/29207074 http://dx.doi.org/10.3892/mmr.2017.8140 |