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Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout

To investigate the role of diacylglycerol kinase θ (DGKθ) in lipid metabolism and insulin resistance, the present study generated an in vitro hepatic steatosis cell model by knockout of the DGKθ gene in liver cancer cell line HepG2 using CRISPR/Cas9 technology. The cell line was characterized by Oil...

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Detalles Bibliográficos
Autores principales:	Zhang, Jingjing, Zhao, Junli, Zheng, Xiaojing, Cai, Kai, Mao, Qinwen, Xia, Haibin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783457/ https://www.ncbi.nlm.nih.gov/pubmed/29207074 http://dx.doi.org/10.3892/mmr.2017.8140

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