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N-cadherin attenuates nucleus pulposus cell senescence under high-magnitude compression

Mechanical compression is important in disc degeneration. N-cadherin (N-CDH)-mediated signaling contributes to the maintenance of the normal nucleus pulposus (NP) cell phenotype and NP matrix biosynthesis. Our preliminary study demonstrated that a high-magnitude compression (20% deformation) promote...

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Detalles Bibliográficos
Autores principales: Niu, Ming, Ma, Fei, Qian, Jun, Li, Junwei, Wang, Tong, Gao, Yuzhen, Jin, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783503/
https://www.ncbi.nlm.nih.gov/pubmed/29257288
http://dx.doi.org/10.3892/mmr.2017.8239