Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K(+) Channel THIK-1

Microglia exhibit two modes of motility: they constantly extend and retract their processes to survey the brain, but they also send out targeted processes to envelop sites of tissue damage. We now show that these motility modes differ mechanistically. We identify the two-pore domain channel THIK-1 a...

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Detalles Bibliográficos
Autores principales: Madry, Christian, Kyrargyri, Vasiliki, Arancibia-Cárcamo, I. Lorena, Jolivet, Renaud, Kohsaka, Shinichi, Bryan, Robert M., Attwell, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783715/
https://www.ncbi.nlm.nih.gov/pubmed/29290552
http://dx.doi.org/10.1016/j.neuron.2017.12.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783715/
https://www.ncbi.nlm.nih.gov/pubmed/29290552
http://dx.doi.org/10.1016/j.neuron.2017.12.002

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