Identification of a potent MAR element from the human genome and assessment of its activity in stably transfected CHO cells

Low‐level and unstable transgene expression are common issues using the CHO cell expression system. Matrix attachment regions (MARs) enhance transgene expression levels, but additional research is needed to improve their function and to determine their mechanism of action. MAR‐6 from CHO chromosomes...

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Detalles Bibliográficos
Autores principales: Tian, Zheng‐Wei, Xu, Dan‐Hua, Wang, Tian‐Yun, Wang, Xiao‐Yin, Xu, Hong‐Yan, Zhao, Chun‐Peng, Xu, Guang‐Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783848/
https://www.ncbi.nlm.nih.gov/pubmed/29077269
http://dx.doi.org/10.1111/jcmm.13361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783848/
https://www.ncbi.nlm.nih.gov/pubmed/29077269
http://dx.doi.org/10.1111/jcmm.13361

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