Inhibition of mitochondrial complex I improves glucose metabolism independently of AMPK activation

Accumulating evidences showed metformin and berberine, well‐known glucose‐lowering agents, were able to inhibit mitochondrial electron transport chain at complex I. In this study, we aimed to explore the antihyperglycaemic effect of complex I inhibition. Rotenone, amobarbital and gene silence of NDU...

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Detalles Bibliográficos
Autores principales: Hou, Wo‐Lin, Yin, Jun, Alimujiang, Miriayi, Yu, Xue‐Ying, Ai, Li‐Gen, Bao, Yu‐qian, Liu, Fang, Jia, Wei‐Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783883/
https://www.ncbi.nlm.nih.gov/pubmed/29106036
http://dx.doi.org/10.1111/jcmm.13432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783883/
https://www.ncbi.nlm.nih.gov/pubmed/29106036
http://dx.doi.org/10.1111/jcmm.13432

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