T cells specific for post-translational modifications escape intrathymic tolerance induction

Establishing effective central tolerance requires the promiscuous expression of tissue-restricted antigens by medullary thymic epithelial cells. However, whether central tolerance also extends to post-translationally modified proteins is not clear. Here we show a mouse model of autoimmunity in which...

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Detalles Bibliográficos
Autores principales: Raposo, Bruno, Merky, Patrick, Lundqvist, Christina, Yamada, Hisakata, Urbonaviciute, Vilma, Niaudet, Colin, Viljanen, Johan, Kihlberg, Jan, Kyewski, Bruno, Ekwall, Olov, Holmdahl, Rikard, Bäcklund, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783942/
https://www.ncbi.nlm.nih.gov/pubmed/29367624
http://dx.doi.org/10.1038/s41467-017-02763-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783942/
https://www.ncbi.nlm.nih.gov/pubmed/29367624
http://dx.doi.org/10.1038/s41467-017-02763-y

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