Cargando…

T cells specific for post-translational modifications escape intrathymic tolerance induction

Establishing effective central tolerance requires the promiscuous expression of tissue-restricted antigens by medullary thymic epithelial cells. However, whether central tolerance also extends to post-translationally modified proteins is not clear. Here we show a mouse model of autoimmunity in which...

Descripción completa

Detalles Bibliográficos
Autores principales:	Raposo, Bruno, Merky, Patrick, Lundqvist, Christina, Yamada, Hisakata, Urbonaviciute, Vilma, Niaudet, Colin, Viljanen, Johan, Kihlberg, Jan, Kyewski, Bruno, Ekwall, Olov, Holmdahl, Rikard, Bäcklund, Johan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783942/ https://www.ncbi.nlm.nih.gov/pubmed/29367624 http://dx.doi.org/10.1038/s41467-017-02763-y

Ejemplares similares

T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis
por: Malmström, Vivianne, et al.
Publicado: (2000)

Cartilage Oligomeric Matrix Protein Induced Arthritis—A New Model for Rheumatoid Arthritis in the C57BL/6 Mouse
por: Zhao, Yunjuan, et al.
Publicado: (2021)

Two major genes associated with autoimmune arthritis, Ncf1 and Fcgr2b, additively protect mice by strengthening T cell tolerance
por: Li, Qijing, et al.
Publicado: (2022)

Standardization of Antigen-Emulsion Preparations for the Induction of Autoimmune Disease Models
por: Topping, Louise M., et al.
Publicado: (2022)

Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor
por: Ge, Changrong, et al.
Publicado: (2022)

Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells
por: Nandakumar, Kutty Selva, et al.
Publicado: (2004)

NIH/3T3 Fibroblasts Selectively Activate T Cells Specific for Posttranslationally Modified Collagen Type II
por: Dzhambazov, Balik, et al.
Publicado: (2023)

Comparative analysis of collagen type II-specific immune responses during development of collagen-induced arthritis in two B10 mouse strains
por: Batsalova, Tsvetelina, et al.
Publicado: (2012)

NCF1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell development and functions
por: Luo, Huqiao, et al.
Publicado: (2023)

The Intrathymic Pathogenesis of Myasthenia Gravis
por: Levinson, Arnold I., et al.
Publicado: (2004)

Primary intrathymic lymphangioma in an infant
por: Hiremath, Channabasavaraj S, et al.
Publicado: (2020)

Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor β-chain
por: Merky, Patrick, et al.
Publicado: (2010)

Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis
por: Li, Yanpeng, et al.
Publicado: (2020)

Neurotransmitters Modulate Intrathymic T-cell Development
por: Francelin, Carolina, et al.
Publicado: (2021)

Protocol for standardized intrathymic injection in mice
por: Tsai, Tsung-Lin, et al.
Publicado: (2023)

A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Humans with Arthritis
por: Tong, Dongmei, et al.
Publicado: (2018)

Intrathymic differentiation of V gamma 3 T cells
Publicado: (1993)

Modulation of Intrathymic Sphingosine-1-Phosphate Levels Promotes Escape of Immature Thymocytes to the Periphery with a Potential Proinflammatory Role in Chagas Disease
por: Flávia Nardy, Ana, et al.
Publicado: (2015)

A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis
por: He, Yibo, et al.
Publicado: (2023)

Nuclear factors that mediate intrathymic signals are developmentally regulated
Publicado: (1994)

Intrathymic Selection and Defects in the Thymic Epithelial Cell Development
por: García-Ceca, Javier, et al.
Publicado: (2020)

Intrathymic somatotropic circuitry: consequences upon thymus involution
por: Reis, Maria Danielma dos Santos, et al.
Publicado: (2023)

The Rheumatoid Arthritis Risk Gene AIRE Is Induced by Cytokines in Fibroblast-Like Synoviocytes and Augments the Pro-inflammatory Response
por: Bergström, Beatrice, et al.
Publicado: (2019)

Early T lymphocytes. Differentiation in vivo of adult intrathymic precursor cells
Publicado: (1985)

Intrathymic Plasmablasts Are Affected in Patients With Myasthenia Gravis With Active Disease
por: Yamamoto, Yohei, et al.
Publicado: (2021)

Technique for ectopic intrathymic parathyroid adenoma: the uniportal subxiphoid approach
por: Hartert, Marc, et al.
Publicado: (2021)

ODP075 A Rare Case of Intrathymic Parathyroid Adenoma
por: Heluey, Camila, et al.
Publicado: (2022)

Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development
por: Bäcklund, Alexandra, et al.
Publicado: (2011)

The genetics of rheumatoid arthritis and the need for animal models to find and understand the underlying genes
por: Jirholt, Johan, et al.
Publicado: (2001)

Design of Glycopeptides Used to Investigate Class II MHC Binding and T-Cell Responses Associated with Autoimmune Arthritis
por: Andersson, Ida E., et al.
Publicado: (2011)

Dynamic Changes During the Immune Response in T Cell–Antigen-presenting Cell Clusters Isolated from Lymph Nodes
por: Hommel, Mirja, et al.
Publicado: (2003)

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer
por: Koble, Christian, et al.
Publicado: (2009)

Differential Effects of Male and Female Gonadal Hormones on the Intrathymic T cell Maturation
por: Pejčić-Karapetrović, Branka, et al.
Publicado: (2001)

Notch1 Deficiency Dissociates the Intrathymic Development of Dendritic Cells and T Cells
por: Radtke, Freddy, et al.
Publicado: (2000)

Split tolerance induced by the intrathymic adoptive transfer of thymocyte stem cells
Publicado: (1988)

An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination
Publicado: (1990)

T Cell Receptor Signaling That Regulates the Development of Intrathymic Natural Regulatory T Cells
por: Song, Ki-Duk, et al.
Publicado: (2011)

Dynamic changes in intrathymic ILC populations during murine neonatal development
por: Jones, Rhys, et al.
Publicado: (2018)

Intrathymic differentiation of natural antibody-producing plasma cells in human neonates
por: Cordero, Hector, et al.
Publicado: (2021)

Intrathymic growing bronchogenic cyst mimicking thymoma: A case report
por: Grigoroiu, Madalina, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_g0l8b8jf8cbcg2gd882o0cvcls