Nicorandil regulates the macrophage skewing and ameliorates myofibroblasts by inhibition of RhoA/Rho‐kinase signalling in infarcted rats

We have demonstrated that ATP‐sensitive potassium (K(ATP)) channel agonists attenuated fibrosis; however, the mechanism remained unclear. Since RhoA has been identified as a mediator of cardiac fibrosis, we sought to determine whether the anti‐fibrotic effects of K(ATP) channel agonists were mediate...

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Detalles Bibliográficos
Autores principales: Lee, Tsung‐Ming, Lin, Shinn‐Zong, Chang, Nen‐Chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783972/
https://www.ncbi.nlm.nih.gov/pubmed/29119680
http://dx.doi.org/10.1111/jcmm.13130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783972/
https://www.ncbi.nlm.nih.gov/pubmed/29119680
http://dx.doi.org/10.1111/jcmm.13130

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