Tryptophan hydroxylase (TRH) loss of function mutations induce growth and behavioral defects in Daphnia magna

Tryptophan hydroxylase (TRH) is the rate limiting enzyme in the serotonin synthesis. CRISPR-Cas9 technology was used to generate seven indel TRH mutants in Daphnia magna. Mono-allelic indel TRH−/+ clones showed normal levels of serotonin, measured by both immunohistochemistry and mass spectrometry (...

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Detalles Bibliográficos
Autores principales: Rivetti, Claudia, Campos, Bruno, Piña, Benjamín, Raldúa, Demetrio, Kato, Yasuhiko, Watanabe, Hajime, Barata, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784079/
https://www.ncbi.nlm.nih.gov/pubmed/29367674
http://dx.doi.org/10.1038/s41598-018-19778-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784079/
https://www.ncbi.nlm.nih.gov/pubmed/29367674
http://dx.doi.org/10.1038/s41598-018-19778-0

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