Cargando…
Tryptophan hydroxylase (TRH) loss of function mutations induce growth and behavioral defects in Daphnia magna
Tryptophan hydroxylase (TRH) is the rate limiting enzyme in the serotonin synthesis. CRISPR-Cas9 technology was used to generate seven indel TRH mutants in Daphnia magna. Mono-allelic indel TRH−/+ clones showed normal levels of serotonin, measured by both immunohistochemistry and mass spectrometry (...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784079/ https://www.ncbi.nlm.nih.gov/pubmed/29367674 http://dx.doi.org/10.1038/s41598-018-19778-0 |