Convergent Evolution Driven by Rifampin Exacerbates the Global Burden of Drug-Resistant Staphylococcus aureus

Mutations in the beta-subunit of bacterial RNA polymerase (RpoB) cause resistance to rifampin (Rif(r)), a critical antibiotic for treatment of multidrug-resistant Staphylococcus aureus. In vitro studies have shown that RpoB mutations confer decreased susceptibility to other antibiotics, but the clin...

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Detalles Bibliográficos
Autores principales: Guérillot, Romain, Gonçalves da Silva, Anders, Monk, Ian, Giulieri, Stefano, Tomita, Takehiro, Alison, Eloise, Porter, Jessica, Pidot, Sacha, Gao, Wei, Peleg, Anton Y., Seemann, Torsten, Stinear, Timothy P., Howden, Benjamin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784246/
https://www.ncbi.nlm.nih.gov/pubmed/29404415
http://dx.doi.org/10.1128/mSphere.00550-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784246/
https://www.ncbi.nlm.nih.gov/pubmed/29404415
http://dx.doi.org/10.1128/mSphere.00550-17

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