Cargando…

Evaluation of Preexisting Anti-Hemagglutinin Stalk Antibody as a Correlate of Protection in a Healthy Volunteer Challenge with Influenza A/H1N1pdm Virus

Influenza virus hemagglutinin (HA) surface glycoprotein is currently the primary target of licensed influenza vaccines. Recently, broadly reactive antibodies that target the stalk region of the HA have become a major focus of current novel vaccine development. These antibodies have been observed in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Jae-Keun, Han, Alison, Czajkowski, Lindsay, Reed, Susan, Athota, Rani, Bristol, Tyler, Rosas, Luz Angela, Cervantes-Medina, Adriana, Taubenberger, Jeffery K., Memoli, Matthew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784259/ https://www.ncbi.nlm.nih.gov/pubmed/29362240 http://dx.doi.org/10.1128/mBio.02284-17

Ejemplares similares

723. Validation of a Wild-Type Influenza A/Texas-Like H3N2 Human Challenge Model with Comparison to the Validated A(H1N1)pdm09 Model
por: Han, Alison, et al.
Publicado: (2018)

2750. Sequential Influenza A H1N1 and Influenza A H3N2 Challenge Infections in Healthy Volunteers
por: Han, Alison, et al.
Publicado: (2019)

Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge Model
por: Memoli, Matthew J., et al.
Publicado: (2016)

1522. Safety and Efficacy of CR6261 in an Influenza A H1N1 Healthy Human Challenge Model
por: Han, Alison, et al.
Publicado: (2020)

The Natural History of Influenza Infection in the Severely Immunocompromised vs Nonimmunocompromised Hosts
por: Memoli, Matthew J., et al.
Publicado: (2014)

Differential Effects of Influenza Virus NA, HA Head, and HA Stalk Antibodies on Peripheral Blood Leukocyte Gene Expression during Human Infection
por: Walters, Kathie-Anne, et al.
Publicado: (2019)

Antigenic Drift of the Influenza A(H1N1)pdm09 Virus Neuraminidase Results in Reduced Effectiveness of A/California/7/2009 (H1N1pdm09)-Specific Antibodies
por: Gao, Jin, et al.
Publicado: (2019)

The effect of calcium and magnesium on activity, immunogenicity, and efficacy of a recombinant N1/N2 neuraminidase vaccine
por: Giurgea, Luca T., et al.
Publicado: (2021)

The hemagglutinin of the influenza A(H1N1)pdm09 is mutating towards stability
por: Castelán-Vega, Juan A, et al.
Publicado: (2014)

Group 1 and group 2 hemagglutinin stalk antibody response according to age
por: Sánchez-de Prada, Laura, et al.
Publicado: (2023)

Analysis of Adaptation Mutants in the Hemagglutinin of the Influenza A(H1N1)pdm09 Virus
por: Jiménez-Alberto, Alicia, et al.
Publicado: (2013)

Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain
por: Anderson, Christopher S., et al.
Publicado: (2017)

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain
por: Steel, John, et al.
Publicado: (2010)

Adjuvants and Immunization Strategies to Induce Influenza Virus Hemagglutinin Stalk Antibodies
por: Goff, Peter H., et al.
Publicado: (2013)

The influenza virus hemagglutinin head evolves faster than the stalk domain
por: Kirkpatrick, Ericka, et al.
Publicado: (2018)

Assessing the Protective Potential of H1N1 Influenza Virus Hemagglutinin Head and Stalk Antibodies in Humans
por: Christensen, Shannon R., et al.
Publicado: (2019)

Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain
por: Anderson, Christopher S., et al.
Publicado: (2018)

Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain
por: Anderson, Christopher S., et al.
Publicado: (2018)

Functional Balance between the Hemagglutinin and Neuraminidase of Influenza A(H1N1)pdm09 HA D222 Variants
por: Casalegno, Jean-Sébastien, et al.
Publicado: (2014)

Hemagglutinin stalk-based monoclonal antibody elicits broadly reactivity against group 1 influenza A virus
por: Huang, Jingjin, et al.
Publicado: (2020)

Age Dependence and Isotype Specificity of Influenza Virus Hemagglutinin Stalk-Reactive Antibodies in Humans
por: Nachbagauer, Raffael, et al.
Publicado: (2016)

Antigenic Site Variation in the Hemagglutinin of Pandemic Influenza A(H1N1)pdm09 Viruses between 2009–2017 in Ukraine
por: Zolotarova, Oksana, et al.
Publicado: (2019)

Antigenic Drift of the Hemagglutinin from an Influenza A (H1N1) pdm09 Clinical Isolate Increases its Pathogenicity In Vitro
por: Xing, Lei, et al.
Publicado: (2021)

Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model
por: Roubidoux, Ericka Kirkpatrick, et al.
Publicado: (2021)

Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses
por: Kawai, Atsushi, et al.
Publicado: (2023)

Immunogenicity of modified vaccinia virus Ankara expressing the hemagglutinin stalk domain of pandemic (H1N1) 2009 influenza virus
por: Di Mario, Giuseppina, et al.
Publicado: (2017)

A Single Amino Acid in the Stalk Region of the H1N1pdm Influenza Virus HA Protein Affects Viral Fusion, Stability and Infectivity
por: Cotter, Christopher R., et al.
Publicado: (2014)

Influenza A H1N1pdm 2009 Virus in Paraguay: Nucleotide Point Mutations in Hemagglutinin and Neuraminidase Genes are not Associated with Drug Resistance
por: Espínola, Emilio E, et al.
Publicado: (2014)

Cell-Based Influenza A/H1N1pdm09 Vaccine Viruses Containing Chimeric Hemagglutinin with Improved Membrane Fusion Ability
por: Kawahara, Madoka, et al.
Publicado: (2020)

Cluster of Oseltamivir-Resistant and Hemagglutinin Antigenically Drifted Influenza A(H1N1)pdm09 Viruses, Texas, USA, January 2020
por: Mohan, Teena, et al.
Publicado: (2021)

An immuno-assay to quantify influenza virus hemagglutinin with correctly folded stalk domains in vaccine preparations
por: Rajendran, Madhusudan, et al.
Publicado: (2018)

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
por: Pardi, Norbert, et al.
Publicado: (2018)

Globular Head-Displayed Conserved Influenza H1 Hemagglutinin Stalk Epitopes Confer Protection against Heterologous H1N1 Virus
por: Klausberger, Miriam, et al.
Publicado: (2016)

Dissecting the hemagglutinin head and stalk-specific IgG antibody response in healthcare workers following pandemic H1N1 vaccination
por: Tete, Sarah M, et al.
Publicado: (2016)

Assessing antigenic drift and phylogeny of influenza A (H1N1) pdm09 virus in Kenya using HA1 sub-unit of the hemagglutinin gene
por: Opanda, Silvanos, et al.
Publicado: (2020)

Influenza virus A(H1N1)pdm09 hemagglutinin polymorphism and associated disease in southern Germany during the 2010/11 influenza season
por: Falcone, Valeria, et al.
Publicado: (2013)

Bioinformatics and Structural Analysis of Antigenic Variation in the Hemagglutinin Gene of the Influenza A(H1N1)pdm09 Virus Circulating in Shiraz (2013 to 2015)
por: Mortazavi, Mojtaba, et al.
Publicado: (2023)

1524. Sex Differences in Influenza: The Challenge Study Experience
por: Giurgea, Luca, et al.
Publicado: (2020)

Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development
por: Khanna, Madhu, et al.
Publicado: (2014)

An Adenovirus-Vectored Influenza Vaccine Induces Durable Cross-Protective Hemagglutinin Stalk Antibody Responses in Mice
por: Kim, Eun Hye, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hilta4ccfht579imlerac4p17o