PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism

OBJECTIVE: Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) promotes hepatic gluconeogenesis by activating HNF4α and FoxO1. PGC-1α expression in the liver is highly elevated in obese and diabetic conditions, leading to increased hepatic glucose production. We previously s...

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Detalles Bibliográficos
Autores principales: Lee, Jaemin, Salazar Hernández, Mario Andrés, Auen, Thomas, Mucka, Patrick, Lee, Justin, Ozcan, Umut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784318/
https://www.ncbi.nlm.nih.gov/pubmed/29129613
http://dx.doi.org/10.1016/j.molmet.2017.10.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784318/
https://www.ncbi.nlm.nih.gov/pubmed/29129613
http://dx.doi.org/10.1016/j.molmet.2017.10.010

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