Notch pathway inhibitor DAPT enhances Atoh1 activity to generate new hair cells in situ in rat cochleae

Atoh1 overexpression in cochlear epithelium induces new hair cell formation. Use of adenovirus-mediated Atoh1 overexpression has mainly focused on the rat lesser epithelial ridge and induces ectopic hair cell regeneration. The sensory region of rat cochlea is difficult to transfect, thus new hair ce...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Wen-wei, Han, Zhao, Ren, Dong-dong, Wang, Xin-wei, Chi, Fang-lu, Yang, Juan-mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784360/
https://www.ncbi.nlm.nih.gov/pubmed/29323051
http://dx.doi.org/10.4103/1673-5374.221169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784360/
https://www.ncbi.nlm.nih.gov/pubmed/29323051
http://dx.doi.org/10.4103/1673-5374.221169

Ejemplares similares