Systems Pharmacology Model of Gastrointestinal Damage Predicts Species Differences and Optimizes Clinical Dosing Schedules

Gastrointestinal (GI) adverse events (AEs) are frequently dose limiting for oncology agents, requiring extensive clinical testing of alternative schedules to identify optimal dosing regimens. Here, we develop a translational mathematical model to predict these clinical AEs starting from preclinical...

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Detalles Bibliográficos
Autores principales: Shankaran, Harish, Cronin, Anna, Barnes, Jen, Sharma, Pradeep, Tolsma, John, Jasper, Paul, Mettetal, Jerome T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784737/
https://www.ncbi.nlm.nih.gov/pubmed/28941225
http://dx.doi.org/10.1002/psp4.12255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784737/
https://www.ncbi.nlm.nih.gov/pubmed/28941225
http://dx.doi.org/10.1002/psp4.12255

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