Structure-based inhibitors of tau aggregation

Aggregated Tau protein is associated with over 20 neurological disorders including Alzheimer’s disease. Previous work has shown that Tau’s sequence segments VQIINK and VQIVYK drive its aggregation, but inhibitors based on the structure of the VQIVYK segment only partially inhibit full-length Tau agg...

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Detalles Bibliográficos
Autores principales: Seidler, PM, Boyer, DR, Rodriguez, JA, Sawaya, MR, Cascio, D, Murray, K, Gonen, T, Eisenberg, DS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784779/
https://www.ncbi.nlm.nih.gov/pubmed/29359764
http://dx.doi.org/10.1038/nchem.2889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784779/
https://www.ncbi.nlm.nih.gov/pubmed/29359764
http://dx.doi.org/10.1038/nchem.2889

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