Evaluation of drug mechanism and efficacy of a novel anti-angiogenic agent, TTAC-0001, using multi-modality bioimaging in a mouse breast cancer orthotopic model

PURPOSE: Targeting of vascular endothelial growth factor receptors (VEGFRs) has potential anti-angiogenic effects because VEGFR-2 is the major signaling regulator of VEGF/VEGFR pathways. We aimed to elucidate the drug mechanism and anti-tumor efficacy of TTAC-0001, a novel, fully human anti-VEGFR-2/...

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Detalles Bibliográficos
Autores principales: Kim, Jinil, Choi, Sang Hyun, Ham, Su Jung, Cho, Young Chul, Lee, Seul-I, Kang, Jeeheon, Woo, Dong-Cheol, Lee, Weon Sub, Yoo, Jin-San, Kim, Kyung Won, Choi, Yoonseok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784895/
https://www.ncbi.nlm.nih.gov/pubmed/29370209
http://dx.doi.org/10.1371/journal.pone.0187063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784895/
https://www.ncbi.nlm.nih.gov/pubmed/29370209
http://dx.doi.org/10.1371/journal.pone.0187063

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